User:Eneumann/Kinases

= Some Kinases =

http://eneumann.org/exhibit/kinase_demo/kinases_vu.html#DAPK1 label::DAPK1 type:=Kinase uri:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html Name:=DAPK1 Disease+Type:=Cancer Disease+Type:=Epilepsy Group:=CAMK Notes:=Putative tumor suppressor, activating p53-dependent apoptosis. Expression is reduced in some cancers, and the promoter is frequently hypermethylated in invasive cancers. Increased expression and mislocalization is seen in epilepsy, where it may regulate neuronal death. OMIM Gene Id: 600831. OMIM:=600831 Molecular+Basis:=Methylation Molecular+Basis:=Expression origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/kinases_vu.html#PIM2 label::PIM2 type:=Kinase uri:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html Name:=PIM2 Disease+Type:=Cancer Group:=CAMK Notes:=Similar to PIM1, mouse T cell lymphomas are induced by a PIM2 transgene, and by viral insertions. OMIM Gene Id: 300295. OMIM:=300295 origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/kinases_vu.html#PIM1 label::PIM1 type:=Kinase type:=Mutant_Gene uri:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html Name:=PIM1 Name:=pim-1 oncogene Disease+Type:=Cancer Group:=CAMK Notes:=Expression increased in prostate cancer, where it may lead to genomic instability (Medline:14678956) and reduce androgen receptor-dependent transcription (Medline:13679438). Expression level has prognostic value. Overexpression also seen in hematopoeitic malignancies, and is a target of aberrant somatic hypermutation in diffuse large-cell lymphomas. T-cell lymphomas are induced in Pim1 transgenic mice and by frequent viral insertions at the Pim1 locus. OMIM Gene Id: 164960. OMIM:=164960 Molecular+Basis:=Translocation Molecular+Basis:=Overexpression Molecular+Basis:=Mutation Tissue:=L Canc_Mol_Genetics:=Dom Tum_Soma_Mut:=NHL Mut_Type:=T Transloc_Partner::BCL6 Chr_Band:=6p21.2 Cancer_Mut:=Somatic =6 Symbol::PIM1 GeneID:=5292 origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/kinases_vu.html#CHK2 label::CHK2 type:=Kinase type:=Mutant_Gene uri:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html Name:=CHK2 Name:=CHK2 checkpoint homolog (S. pombe) Disease+Type:=Cancer Group:=CAMK Notes:=Tumor suppressor, involved in DNA damage and cell cycle arrest. LOF mutants cause Li-Fraumeni syndrome [MIM:151623], a highly penetrant familial cancer phenotype also caused by p53 mutations. Familial mutations also associated with prostate and breast cancer, and mutations also seen in a variety of sporadic cancers and cell lines. OMIM Gene Id: 604373. OMIM:=604373 Molecular+Basis:=Mutation Tissue:=E Canc_Mol_Genetics:=Rec Mut_Type:=F Chr_Band:=22q12.1 Tum_Germ_Mut:=breast Cancer_Mut:=Germline Canc_Syndrome:=familial breast cancer =22 Symbol::CHEK2 GeneID:=11200 origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/kinases_vu.html#PIM3 label::PIM3 type:=Kinase uri:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html Name:=PIM3 Disease+Type:=Cancer Group:=CAMK Notes:=May substitute for PIM1 and PIM2 in mouse virally driven cancer models (Medline:12185366). OMIM Gene Id:. origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/item#LKB1%20(STK11) label::LKB1 (STK11) type:=Kinase uri:=http://eneumann.org/exhibit/kinase_demo/item Name:=LKB1 (STK11) Disease+Type:=Cancer Group:=CAMK Notes:=Several distinct loss of function point mutants cause Peutz-Jeghers syndrome [MIM:175200], causing gastrointestinal polyps and cancer susceptibility. Sporadic mutations also seen in melanoma, pancreatic cancer and testicular cancer. OMIM Gene Id: 602216. OMIM:=602216 Molecular+Basis:=Loss-of-function Mutation origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/item#PHKgamma2 label::PHKgamma2 type:=Kinase uri:=http://eneumann.org/exhibit/kinase_demo/item Name:=PHKgamma2 Disease+Type:=Metabolism Group:=CAMK Notes:=LOF mutations cause liver glycogenosis and one form of liver cirrhosis. OMIM Gene Id: 172471. OMIM:=172471 Molecular+Basis:=Loss-of-function Mutation origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/item#skMLCK%20(MYLK2) label::skMLCK (MYLK2) type:=Kinase uri:=http://eneumann.org/exhibit/kinase_demo/item Name:=skMLCK (MYLK2) Disease+Type:=Cardiovascular Group:=CAMK Notes:=A single case of familial hypertrophic cardiomyopathy [MIM:192600] has been linked to a mutation in skMLCK. OMIM Gene Id: 606566. OMIM:=606566 Molecular+Basis:=Mutation origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html

http://eneumann.org/exhibit/kinase_demo/item#CHK1 label::CHK1 type:=Kinase uri:=http://eneumann.org/exhibit/kinase_demo/item Name:=CHK1 Disease+Type:=Cancer Group:=CAMK Notes:=Cell cycle G2 checkpoint kinase, implicated in resistance to apoptosis in response to chemotherapy. Inhibitors under development to chemosensitize tumors. Somatic mutations found in stomach tumors (Medline:11691784), and in colon and endometrial tumors, where CHK1 may be a target of microsatellite instability (Medline:14657665). Inhibitors: SB218078, UNC-01. OMIM Gene Id: 603078. OMIM:=603078 Molecular+Basis:=Mutation origin:=http://eneumann.org/exhibit/kinase_demo/kinases_vu.html