Thread:Project:Support desk/Sending email redirects to blank on attempted mail send/reply (9)

I doubt mod_wsgi is causing this.

You should enable MediaWiki's debug log to see what it's doing before having that timeout, to ensure what host is really trying to connect. A timeout usually is caused by firewall not allowing connections, or a typo or error when setting up the hostname or port of the destination SMTP server if the server isn't listening to that port.