Thread:Project:Support desk/Two domain for one installation/reply

yes, LocalSettings.php is a config file. You can use if statements in the config file to change the value of $wgSkin, etc. You may want to add something to $wgRenderHashAppend for the different domains, or, etc [including some urls] will be wrong on some pages. Also make sure that $wgServer is either not included (so its autodetected) or that its correct for the different domains.