Thread:Project:Support desk/Personal wiki/reply

Yes, but you need to install a webserver (and php, and a db engine. If its just your personal use, sqlite may be the easiest choice). Apache is a webserver that is available for almost every platform imaginable (if you're on Windows, see WAMP). Its not something that people do all that often, but its certainly do-able. (I have several copies of MediaWiki installed on my computer, some of which I use to keep notes in. However I'm a MediaWiki developer, so I'm not quite your average user)

Alternatively you can look into something like TiddlyWiki which is something developed with a use case closer to what you're asking for.